Glucocorticoids Oppose Thymocyte Negative Selection by Inhibiting Helios and Nur77
نویسندگان
چکیده
منابع مشابه
Thymus-derived glucocorticoids set the thresholds for thymocyte selection by inhibiting TCR-mediated thymocyte activation.
Selection processes in the thymus eliminate nonfunctional or harmful T cells and allow the survival of those cells with the potential to recognize Ag in association with self-MHC-encoded molecules (Ag/MHC). We have previously demonstrated that thymus-derived glucocorticoids antagonize TCR-mediated deletion, suggesting a role for endogenous thymic glucocorticoids in promoting survival of thymocy...
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ژورنال
عنوان ژورنال: The Journal of Immunology
سال: 2019
ISSN: 0022-1767,1550-6606
DOI: 10.4049/jimmunol.1900559